2021
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Inthavong, Kiao; Wong, Eugene; Tu, Jiyuan; Singh, Narinder (Ed.) Clinical and Biomedical Engineering in the Human Nose Book Springer, 2021, ISBN: 978-981-15-6716-2. @book{inthavong2021clinicalb,
title = {Clinical and Biomedical Engineering in the Human Nose},
editor = {Inthavong, Kiao and Wong, Eugene and Tu, Jiyuan and Singh, Narinder},
url = {https://link.springer.com/book/10.1007/978-981-15-6716-2#toc},
isbn = {978-981-15-6716-2},
year = {2021},
date = {2021-01-01},
publisher = {Springer},
abstract = {This book explores computational fluid dynamics in the context of the human nose, allowing readers to gain a better understanding of its anatomy and physiology and integrates recent advances in clinical rhinology, otolaryngology and respiratory physiology research. It focuses on advanced research topics, such as virtual surgery, AI-assisted clinical applications and therapy, as well as the latest computational modeling techniques, controversies, challenges and future directions in simulation using CFD software. Presenting perspectives and insights from computational experts and clinical specialists (ENT) combined with technical details of the computational modeling techniques from engineers, this unique reference book will give direction to and inspire future research in this emerging field.},
keywords = {Computational Fluid Dynamics, Convolutional Neural Networks, Nasal cavity flows, Respiratory Flow Computation},
pubstate = {published},
tppubtype = {book}
}
This book explores computational fluid dynamics in the context of the human nose, allowing readers to gain a better understanding of its anatomy and physiology and integrates recent advances in clinical rhinology, otolaryngology and respiratory physiology research. It focuses on advanced research topics, such as virtual surgery, AI-assisted clinical applications and therapy, as well as the latest computational modeling techniques, controversies, challenges and future directions in simulation using CFD software. Presenting perspectives and insights from computational experts and clinical specialists (ENT) combined with technical details of the computational modeling techniques from engineers, this unique reference book will give direction to and inspire future research in this emerging field. | |
2020
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Lintermann, Andreas Computational Meshing for CFD Simulations Book Chapter In: Ithavong, Kiao; Singh, Narinder; Wong, Eurgene; Tu, Jiyuang (Ed.): Clinical and Biomedical Engineering in the Human Nose - A Computational Fluid Dynamics Approach, Chapter 6, pp. 85-115, Springer Nature Singapore Pte Ltd. 2021, 2020, ISBN: 978-981-15-6715-5. @inbook{Lintermann2020d,
title = {Computational Meshing for CFD Simulations},
author = {Lintermann, Andreas},
editor = {Ithavong, Kiao and Singh, Narinder and Wong, Eurgene and Tu, Jiyuang},
url = {https://link.springer.com/chapter/10.1007%2F978-981-15-6716-2_6},
doi = {10.1007/978-981-15-6716-2_6},
isbn = {978-981-15-6715-5},
year = {2020},
date = {2020-10-17},
booktitle = {Clinical and Biomedical Engineering in the Human Nose - A Computational Fluid Dynamics Approach},
pages = {85-115},
publisher = {Springer Nature Singapore Pte Ltd. 2021},
chapter = {6},
abstract = {In CFD modelling, small cells or elements are created to fill this volume. They constitute a mesh where each cell represents a discrete space that represents the flow locally. Mathematical equations that represent the flow physics are then applied to each cell of the mesh. Generating a high quality mesh is extremely important to obtain reliable solutions and to guarantee numerical stability. This chapter begins with a basic introduction to a typical workflow and guidelines for generating high quality meshes, and concludes with some more advanced topics, i.e., how to generate meshes in parallel, a discussion on mesh quality, and examples on the application of lattice-Boltzmann methods to simulate flow without any turbulence modelling on highly-resolved meshes.},
keywords = {Computational Fluid Dynamics, Mesh Generation, Nasal cavity flows, Nasal respiration, Strömungssimulation},
pubstate = {published},
tppubtype = {inbook}
}
In CFD modelling, small cells or elements are created to fill this volume. They constitute a mesh where each cell represents a discrete space that represents the flow locally. Mathematical equations that represent the flow physics are then applied to each cell of the mesh. Generating a high quality mesh is extremely important to obtain reliable solutions and to guarantee numerical stability. This chapter begins with a basic introduction to a typical workflow and guidelines for generating high quality meshes, and concludes with some more advanced topics, i.e., how to generate meshes in parallel, a discussion on mesh quality, and examples on the application of lattice-Boltzmann methods to simulate flow without any turbulence modelling on highly-resolved meshes. | |
Feng, Yu; Hayati, Hamideh; Bates, Alister J.; Walter, Koch; Matthias, Lehner; Odo, Benda; Ramiro, Ortiz; Gerda, Koch Clinical CFD Applications 2 Book Chapter In: Ithavong, Kiao; Singh, Narinder; Wong, Eurgene; Tu, Jiyuang (Ed.): Clinical and Biomedical Engineering in the Human Nose - A Computational Fluid Dynamics Approach, vol. 1, Chapter 10, pp. 225-253, Springer Nature Singapore Pte Ltd. 2021, 1, 2020, ISBN: 978-981-15-6715-5. @inbook{Koch2020,
title = {Clinical CFD Applications 2},
author = {Yu Feng and Hamideh Hayati and Alister J. Bates and Koch Walter and Lehner Matthias and Benda Odo and Ortiz Ramiro and Koch Gerda },
editor = {Ithavong, Kiao and Singh, Narinder and Wong, Eurgene and Tu, Jiyuang},
url = {https://link.springer.com/chapter/10.1007/978-981-15-6716-2_10},
doi = {10.1007/978-981-15-6716-2_10},
isbn = {978-981-15-6715-5},
year = {2020},
date = {2020-10-17},
booktitle = {Clinical and Biomedical Engineering in the Human Nose - A Computational Fluid Dynamics Approach},
volume = {1},
pages = {225-253},
publisher = {Springer Nature Singapore Pte Ltd. 2021},
edition = {1},
chapter = {10},
abstract = {This chapter is the second of the two chapters demonstrating the wide variety of CFD studies in clinical applications presented from leading researchers in their respective fields. This chapter covers the latest research techniques and outcomes in whole lung modelling; Modeling the Effect of Airway Motion Using Dynamic Imaging; and Automatic reconstruction of the nasal geometry from CT scans.},
keywords = {Artificial Intelligence, Automated Segmentation, CFD Applications, Convolutional Neural Networks, Mesh Generation, Nasal cavity flows},
pubstate = {published},
tppubtype = {inbook}
}
This chapter is the second of the two chapters demonstrating the wide variety of CFD studies in clinical applications presented from leading researchers in their respective fields. This chapter covers the latest research techniques and outcomes in whole lung modelling; Modeling the Effect of Airway Motion Using Dynamic Imaging; and Automatic reconstruction of the nasal geometry from CT scans. | |
Waldmann, Moritz; Lintermann, Andreas; Choi, Yoon Jeong; Schröder, Wolfgang Analysis of the Effects of MARME Treatment on Respiratory Flow Using the Lattice-Boltzmann Method Proceedings Article In: New Results in Numerical and Experimental Fluid Mechanics , pp. 853-863, Springer International Publishing, Darmstadt, Germany, 2020. @inproceedings{Waldmann2020,
title = {Analysis of the Effects of MARME Treatment on Respiratory Flow Using the Lattice-Boltzmann Method},
author = {Waldmann, Moritz and Lintermann, Andreas and Choi, Yoon Jeong and Schröder, Wolfgang },
url = {http://link.springer.com/10.1007/978-3-030-25253-3},
doi = {10.1007/978-3-030-25253-3_80},
year = {2020},
date = {2020-01-02},
booktitle = {New Results in Numerical and Experimental Fluid Mechanics },
volume = {XII},
pages = {853-863},
publisher = {Springer International Publishing},
address = {Darmstadt, Germany},
abstract = {Transverse maxillary deficiency is a common pathological condition. Patients suffering from this pathology often have narrowed airways compared to healthy humans. To cure such an anatomic defective position, a new method, the Miniscrew-Assisted Rapid Maxillary Expansion (MARME), has been developed. In previous studies, the effects of this treatment on respiration have been analyzed by examining the volume of a nasal cavity and the corresponding nasopharynx before and after treatment. In this study the fluid mechanical effects of MARME treatment on the respiratory flow and on the breathing capability are analyzed numerically. The realistic three-dimensional geometries of the nasal cavity employed for the simulation are reconstructed from Computer Tomography images. The flow within these geometries is simulated using a thermal Lattice-Boltzmann method. The results confirm that the respiratory resistance and the average wall-shear stress decrease after the MARME treatment. The heating capability, however, deteriorates.},
keywords = {Lattice-Boltzmann method, MARME, Nasal cavity flows},
pubstate = {published},
tppubtype = {inproceedings}
}
Transverse maxillary deficiency is a common pathological condition. Patients suffering from this pathology often have narrowed airways compared to healthy humans. To cure such an anatomic defective position, a new method, the Miniscrew-Assisted Rapid Maxillary Expansion (MARME), has been developed. In previous studies, the effects of this treatment on respiration have been analyzed by examining the volume of a nasal cavity and the corresponding nasopharynx before and after treatment. In this study the fluid mechanical effects of MARME treatment on the respiratory flow and on the breathing capability are analyzed numerically. The realistic three-dimensional geometries of the nasal cavity employed for the simulation are reconstructed from Computer Tomography images. The flow within these geometries is simulated using a thermal Lattice-Boltzmann method. The results confirm that the respiratory resistance and the average wall-shear stress decrease after the MARME treatment. The heating capability, however, deteriorates. | |
2018
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Kim, Soo-Yeon; Park, Young-Chel; Lee, Kee-Joon; Lintermann, Andreas; Han, Sang-Sun; Yu, Hyung-Seog; Choi, Yoon Jeong Assessment of changes in the nasal airway after nonsurgical miniscrew-assisted rapid maxillary expansion in young adults Journal Article In: The Angle Orthodontist, pp. 092917–656.1, 2018, ISSN: 0003-3219. @article{Kim2018,
title = {Assessment of changes in the nasal airway after nonsurgical miniscrew-assisted rapid maxillary expansion in young adults},
author = {Kim, Soo-Yeon and Park, Young-Chel and Lee, Kee-Joon and Lintermann, Andreas and Han, Sang-Sun and Yu, Hyung-Seog and Choi, Yoon Jeong},
editor = {The Angle Orthodontist},
url = {https://rhinodiagnost.eu/wp-content/uploads/2018/04/092917-656.1_Kim2018.pdf},
doi = {www.angle.org/doi/10.2319/092917-656.1},
issn = {0003-3219},
year = {2018},
date = {2018-03-23},
journal = {The Angle Orthodontist},
pages = {092917--656.1},
abstract = {Objectives: To evaluate changes in the volume and cross-sectional area of the nasal airway before and 1 year after nonsurgical miniscrew-assisted rapid maxillary expansion (MARME) in young adults.
Materials and Methods: Fourteen patients (mean age, 22.7 years; 10 women, four men) with a transverse discrepancy who underwent cone beam computed tomography before (T0), immediately after (T1), and 1 year after (T2) expansion were retrospectively included in this study. The volume of the nasal cavity and nasopharynx and the cross-sectional area of the anterior, middle, and posterior segments of the nasal airway were measured and compared among the three timepoints using paired t-tests.
Results: The volume of the nasal cavity showed a significant increase at T1 and T2 (P < .05), while that of the nasopharynx increased only at T2 (P < .05). The anterior and middle cross-sectional areas significantly increased at T1 and T2 (P < .05), while the posterior cross-sectional area showed no significant change throughout the observation period (P > .05).
Conclusions: The results demonstrate that the volume and cross-sectional area of the nasal cavity increased after MARME and were maintained at 1 year after expansion. Therefore, MARME may be helpful in expanding the nasal airway.
},
keywords = {Airway, MARME, Nasal cavity flows, Nasal respiration, Respiratory Flow Computation},
pubstate = {published},
tppubtype = {article}
}
Objectives: To evaluate changes in the volume and cross-sectional area of the nasal airway before and 1 year after nonsurgical miniscrew-assisted rapid maxillary expansion (MARME) in young adults.
Materials and Methods: Fourteen patients (mean age, 22.7 years; 10 women, four men) with a transverse discrepancy who underwent cone beam computed tomography before (T0), immediately after (T1), and 1 year after (T2) expansion were retrospectively included in this study. The volume of the nasal cavity and nasopharynx and the cross-sectional area of the anterior, middle, and posterior segments of the nasal airway were measured and compared among the three timepoints using paired t-tests.
Results: The volume of the nasal cavity showed a significant increase at T1 and T2 (P < .05), while that of the nasopharynx increased only at T2 (P < .05). The anterior and middle cross-sectional areas significantly increased at T1 and T2 (P < .05), while the posterior cross-sectional area showed no significant change throughout the observation period (P > .05).
Conclusions: The results demonstrate that the volume and cross-sectional area of the nasal cavity increased after MARME and were maintained at 1 year after expansion. Therefore, MARME may be helpful in expanding the nasal airway.
| |
2017
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Lintermann, Andreas; Schröder, Wolfgang A Hierarchical Numerical Journey through the Nasal Cavity: From Nose-Like Models to Real Anatomies Journal Article In: Flow, Turbulence and Combustion, 2017, ISSN: 1386-6184. @article{Lintermann2017FTaC,
title = {A Hierarchical Numerical Journey through the Nasal Cavity: From Nose-Like Models to Real Anatomies},
author = {Lintermann, Andreas and Schröder, Wolfgang},
editor = {Springer Netherlands},
url = {http://rhinodiagnost.eu/wp-content/uploads/2017/12/paper_FTAC_SI_health_Lintermann.pdf, A Hierarchical Numerical Journey through the Nasal Cavity: From Nose-Like Models to Real Anatomies},
doi = {10.1007/s10494-017-9876-0},
issn = {1386-6184},
year = {2017},
date = {2017-12-20},
issuetitle = {special issue "CFD in Health"},
journal = {Flow, Turbulence and Combustion},
abstract = {The immense increase of computational power in the past decades led to an evolution of numerical simulations in all kind of engineering applications. New developments in medical technologies in rhinology employ computational fluid dynamics methods to explore pathologies from a fluid-mechanics point of view. Such methods have grown mature and are about to enter daily clinical use to support doctors in decision making. In light of the importance of effective respiration on patient comfort and health care costs, individualized simulations ultimately have the potential to revolutionize medical diagnosis, drug delivery, and surgery planning. The present article reviews experiments, simulations, and algorithmic approaches developed at RWTH Aachen University that have evolved from fundamental physical analyses using nose-like models to patient-individual analyses based on realistic anatomies and high resolution computations in hierarchical manner.},
keywords = {Digital particle image velocimetry, Finite volume method, High performance computing, Lattice-Boltzmann method, Nasal cavity flows},
pubstate = {published},
tppubtype = {article}
}
The immense increase of computational power in the past decades led to an evolution of numerical simulations in all kind of engineering applications. New developments in medical technologies in rhinology employ computational fluid dynamics methods to explore pathologies from a fluid-mechanics point of view. Such methods have grown mature and are about to enter daily clinical use to support doctors in decision making. In light of the importance of effective respiration on patient comfort and health care costs, individualized simulations ultimately have the potential to revolutionize medical diagnosis, drug delivery, and surgery planning. The present article reviews experiments, simulations, and algorithmic approaches developed at RWTH Aachen University that have evolved from fundamental physical analyses using nose-like models to patient-individual analyses based on realistic anatomies and high resolution computations in hierarchical manner. | |